Polynucleotide (PN)
Polynucleotide (PN) therapy is an advanced skin-regeneration injectable treatment designed to repair, rejuvenate, and improve overall skin quality at a cellular level. It focuses on skin healing and regeneration, rather than volume or muscle relaxation. Polynucleotides are often referred to as “skin repair injectables” and are widely used in medical aesthetics and regenerative medicine.
What Are Polynucleotides?
Polynucleotides are highly purified DNA fragments, commonly derived from salmon or trout DNA, which are biocompatible with human skin. They stimulate the skin’s natural repair processes by improving cellular activity and tissue regeneration.
Popular PN products include Nucleofill®, Plinest®, Rejuran®, and PhilArt®.
How Polynucleotides Work
Polynucleotides work at a cellular level by:
Stimulating fibroblasts (cells that produce collagen and elastin)
Improving skin elasticity and thickness
Enhancing hydration retention
Reducing inflammation
Repairing damaged skin tissue
They also act as powerful antioxidants, protecting the skin from environmental damage.
Common Treatment Areas
Face
Under-eye area
Neck
Décolletage
Hands
Acne-scarred skin
Benefits of Polynucleotide Treatment
✔ Improves skin quality and texture
✔ Stimulates collagen and elastin production
✔ Enhances skin elasticity and firmness
✔ Reduces fine lines and crepey skin
✔ Brightens and refreshes dull skin
✔ Improves acne scars and damaged skin
✔ Ideal for delicate areas (especially under eyes)
✔ Natural and gradual results
Time Duration of the Treatment
Procedure time: 30–45 minutes
Initial results: 7–10 days
Best results: After a course of treatment
Sessions required: 2–4 sessions
Session gap: 2–4 weeks
Duration of results: 6–12 months
Side Effects
Usually mild and temporary.
Common Side Effects
Mild swelling or small bumps at injection sites
Redness
Tenderness
Light bruising
These typically settle within 24–72 hours.
Rare Side Effects
Allergic reaction
Infection
Prolonged swelling
⚠️ Risks are minimal when treatment is performed by trained professionals using authentic products.
Aftercare Instructions
Avoid touching or massaging treated areas for 24 hours
Avoid makeup for 24 hours
Avoid heat, sun exposure, and saunas for 24–48 hours
Avoid strenuous exercise for 24 hours
Stay well hydrated
Who Is a Good Candidate?
Individuals with dull, tired, or aging skin
Early to moderate signs of aging
Thin or fragile skin (especially under eyes)
Acne scars or skin damage
Those wanting skin regeneration rather than volume
Not Recommended For
Pregnant or breastfeeding women
Active skin infections or inflammation
Certain medical conditions (consultation required)